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Taste Receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Taste Receptor (4) Bacterial (2) Cannabinoid Receptor (1) Endogenous Metabolite (1) P2X Receptor (1) Parasite (2)
By Research Areas:	Infection (2) Inflammation/Immunology (1) Metabolic Disease (2)

12

Inhibitors & Agonists

2

Natural
Products

3

Recombinant Proteins

Targets Recommended: Taste Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

FEMA 4774	Taste Receptor	Others
FEMA 4774 is a positive allosteric modulator of taste receptors T1R2 and T1R3, two subunits of the human sweet taste receptor. FEMA 4774 is also used as a sucrose sweetness enhancer .

Perillartine DL-Perillartine	Endogenous Metabolite	Others
Perillartine is a sweetener, which activates the taste receptor type 1 member 2 (Tas1r2) subunit in a species-dependent manner.

HY-W030796A

Lactisole	Taste Receptor	Metabolic Disease
Lactisole is a canonical antagonist of sweet **taste receptor, selectively targeting to T1R3** subunit, a glucose-sensing receptor. Lactisole inhibits insulin secretion induced by glucose in mouse islets .

Nα,Nα-Bis(carboxymethyl)-L-lysine
Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of *bitter taste* receptor 4, with an IC₅₀** of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study .

Adenosine 5'-succinate	Taste Receptor	Others
Adenosine 5'-succinate is a chemically AMP-related compound and potently inhibits Denatonium benzoate/taste receptor activation of transducin .

GIV3727	Taste Receptor	Others
GIV3727 is a bitter taste receptor hTAS2R antagonist, which can inhibit the activation of hTAS2R31 by saccharin and acesulfame potassium, and can effectively reduce the bitter quality of food, beverage and medicine .

Absinthin	Others	Others
Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca ²⁺-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46 .

Ethylhydrocupreine Optochin	Bacterial Parasite	Infection
Ethylhydrocupreine (Optochin) is a quinine derivate with antimicrobial activity against *S. pneumoniae. Ethylhydrocupreine also possesses antimalarial activity against Plasmodium falciparum, with an IC₅₀* of 25.75 nM. Ethylhydrocupreine is a **Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7**) agonist .

Ethylhydrocupreine hydrochloride Optochin hydrochloride	Bacterial Parasite	Infection
Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against *S. pneumoniae. Ethylhydrocupreine hydrochloride also possesses antimalarial activity against Plasmodium falciparum, with an IC₅₀* of 25.75 nM. Ethylhydrocupreine hydrochloride is a **Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7**) agonist .

Camlipixant BLU-5937	P2X Receptor	Inflammation/Immunology
Camlipixant (BLU-5937) a potent, selective, non-competitive and orally active P2X3 homotrimeric receptor antagonist with an IC₅₀ of 25 nM against hP2X3 homotrimeric. Camlipixant shows potent anti-tussive effect and no taste alteration. Camlipixant can be used for the research of unexplained, refractory chronic cough .

HY-153264

TAS2R14 agonist-1

Others Others

TAS2R14 agonist is a potent TAS2R14 partial agonist with an EC₅₀ of 116.6 ±23.6 nM .

AM6545	Cannabinoid Receptor	Metabolic Disease
AM6545 is a peripherally active, cannabinoid receptor antagonist with limited brain penetration. AM6545 binds to CB1 and CB2 receptors with K_is of 1.7 nM and 523 nM, respectively. AM6545 is a neutral antagonist. AM6545 can be used for the research of obesity and its complications .

Species:	Human (3)
Tag:	His (3)
Source:	E. coli Cell-free (3)

Cat. No.	Compare	Product Name	Species	Source

	TAS1R2 Protein, Human (Cell-Free, His) Taste Receptor type 1 member 2; G-protein coupled Receptor 71; Sweet Taste Receptor T1R2	Human	E. coli Cell-free
	TAS1R2 Protein, a putative taste receptor, recognizes various natural and synthetic sweeteners as part of a heterodimeric complex with TAS1R3. Crucial for sweetness perception, its ability to respond to diverse sweet compounds underscores its significance in taste sensation. Further studies are needed to unveil comprehensive molecular mechanisms and its contribution to taste perception with different sweet stimuli. TAS1R2 Protein, Human (Cell-Free, His) is the recombinant human-derived TAS1R2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of TAS1R2 Protein, Human (Cell-Free, His) is 820 a.a., with molecular weight of 99.1 kDa.

	TAS1R2 Protein, Human (Cell-Free, 273a.a, His) Taste Receptor type 1 member 2; G-protein coupled Receptor 71; Sweet Taste Receptor T1R2	Human	E. coli Cell-free
	TAS1R2 Protein, a putative taste receptor, recognizes various natural and synthetic sweeteners as part of a heterodimeric complex with TAS1R3. Crucial for sweetness perception, its ability to respond to diverse sweet compounds underscores its significance in taste sensation. Further studies are needed to unveil comprehensive molecular mechanisms and its contribution to taste perception with different sweet stimuli. TAS1R2 Protein, Human (Cell-Free, 273a.a, His) is the recombinant human-derived TAS1R2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of TAS1R2 Protein, Human (Cell-Free, 273a.a, His) is 273 a.a., with molecular weight of 32.0 kDa.

	TAS2R13 Protein, Human (Cell-Free, His) Taste Receptor type 2 member 13; Taste Receptor family B member 3; TRB3	Human	E. coli Cell-free
	TAS2R13 Protein, a receptor possibly involved in bitter taste perception, is linked to gustducin. It likely contributes to sensing the chemical composition of gastrointestinal content. Activation of this receptor stimulates alpha gustducin, triggers PLC-beta-2 activation, and results in the gating of TRPM5, indicating its role in bitter taste transduction and gustatory signaling pathways. TAS2R13 Protein, Human (Cell-Free, His) is the recombinant human-derived TAS2R13 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of TAS2R13 Protein, Human (Cell-Free, His) is 303 a.a., with molecular weight of 36.6 kDa.

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